Chronic Pruritus
SPSR20791 (CPUO)

Chronic Pruritus of Unknown Origin (CPUO) is a condition where persistent itching lasts 6 weeks or longer without a clear cause. For many people, this itch impacts sleep, daily activities, and overall quality of life.

This study, SPR20791, is evaluating an investigational option to better understand and potentially help those affected.

Who Can Join?

You may qualify if you:

Are 18 years or older
Have experienced persistent itching for at least 6 weeks
Have no known underlying cause for your symptoms
Meet additional study criteria

What You’ll Receive:

Study-related medical care and evaluations at no cost
The opportunity to contribute to research that may improve care for future patients
Reimbursement for time and travel may be available

If you are seeking new and innovate treatment options, give us a call today to schedule a screening!

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If you are interested in participating or would like more information,just give us a call.

Understanding Chronic Pruritus of Unknown Origin (CPUO): Causes, Effects, and Emotional Impact

What is CPUO?

Chronic Pruritus of Unknown Origin (CPUO) is a condition where persistent itching lasts for six weeks or longer without an identifiable underlying cause. Unlike itching linked to allergies, eczema, or other skin disorders, CPUO has no clear trigger, making it especially difficult to manage. Although it is not contagious, CPUO can significantly impact daily life and overall well-being due to its ongoing and disruptive symptoms.

What Causes CPUO?

The exact cause of CPUO is not fully understood, but it is believed to involve multiple factors, including:

Nervous system changes: Abnormal signals between the skin and nerves that amplify the itch response.
Immune system irregularities: Overactive inflammatory responses despite no clear skin disease.
Environmental or internal triggers: Stress, climate, or other unknown factors that worsen symptoms.

Because the underlying cause remains unidentified, treatment can be challenging, and symptoms often persist.

Physical Effects

CPUO symptoms are primarily skin-related but can vary in severity. Common physical signs include:

Ongoing, intense itching without visible rash
Scratching that leads to redness, irritation, or sores
Skin thickening or scaling in chronic cases
Sleep disruption due to night-time itching

These effects may also increase the risk of secondary infections from repeated scratching.

Emotional and Psychological Effects

Living with CPUO can be as emotionally taxing as it is physically uncomfortable. Individuals often report:

Anxiety or depression related to constant discomfort
Sleep loss that worsens fatigue and mood
Social withdrawal due to embarrassment about scratching
Reduced quality of life from persistent, unexplained symptoms

Addressing the mental and emotional toll is an essential part of managing CPUO.

Chronic Pruritus SPSR20791 (CPUO)

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